Synthesis and biological evaluation of novel Jiyuan Oridonin A-1,2,3-triazole-azole derivatives as antiproliferative agents

A focused library of Jiyuan Oridonin A-1,2,3-triazole-azole derivatives were designed and synthesis. Compound 8b displayed the most potent inhibition against SMMC-7721 cells, inhibited colony formation and migration of SMMC-7721, as well as induced apoptosis.245