کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
11014190 1794053 2018 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Utilisation des allergènes recombinants en immunothérapie allergénique
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ایمونولوژی، آلرژی و روماتولوژی
پیش نمایش صفحه اول مقاله
Utilisation des allergènes recombinants en immunothérapie allergénique
چکیده انگلیسی
Molecular allergens, and more particularly those obtained through genetic recombination, have been investigated in allergenic immunotherapy clinical trials. The first publications, published some 15 years ago, first concerned five recombinant major timothy pollen allergens followed by the major birch pollen allergen rBet v 1. With both subcutaneous and sublingual administration, the results were positive, but involved tolerability problems comparable to those encountered with whole extracts. Recombinant allergens modified by chemical denaturation or segmented into peptides or mosaics are used to reduce IgE reactivity while conserving their tolerogenic properties. While most of these studies are currently underway, the results already appear promising, although much still remains to be done before the substances may be widely used in use in actual therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revue Française d'Allergologie - Volume 58, Issue 6, October 2018, Pages 463-467
نویسندگان
, ,