کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11021426 | 1714576 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Simulation of Cefoselis hydrochloride adsorption on macroporous resin in a fixed-bed column using orthogonal collocation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Simulation of Cefoselis hydrochloride adsorption on macroporous resin in a fixed-bed column using orthogonal collocation Simulation of Cefoselis hydrochloride adsorption on macroporous resin in a fixed-bed column using orthogonal collocation](/preview/png/11021426.png)
چکیده انگلیسی
Adsorption operation is of great importance for separation and purification of semi-synthetic cephalosporin compounds in pharmaceutical industry. The adsorption dynamics of Cefoselis hydrochloride (CFH) on XR 920C adsorbent in fixed bed was predicted by the model of modified film-pore diffusion (MFPD). The intraparticle diffusion equation and mass balance equation in fixed bed are discretized into two ordinary differential equations (ODEs) using the method of orthogonal collocation which largely improves the calculation accuracy. The MFPD model parameters including the pore diffusion coefficient (Dp), external mass-transfer coefficient (kf), and the axial dispersion (DL) were estimated. The kf value was calculated by the Carberry equation, in which the effective diffusion coefficient De was fitted based on Crank Model through experimental data. Moreover, three key operating parameters (i.e., initial adsorbate concentration; flow rate of import feed, and bed height of adsorbent) and the corresponded breakthrough curves were systematically studied and optimized. Therefore, this research not only provides valuable experimental data, but also a successfully mathematical model for designing the continuous chromatographic adsorption process of CFH.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Journal of Chemical Engineering - Volume 26, Issue 9, September 2018, Pages 1822-1828
Journal: Chinese Journal of Chemical Engineering - Volume 26, Issue 9, September 2018, Pages 1822-1828
نویسندگان
Feng Xue, Fugang Wang, Shuai Chen, Sheng Wang, Shengui Ju, Weihong Xing,