کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11022630 | 1701476 | 2019 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Associations between PTPN2 gene polymorphisms and psoriasis in Northeastern China
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کلمات کلیدی
CNVPTPN2ORSPTPHWENGS95% CI - 95٪ CIJAK/STAT - JAK / STATHardy-Weinberg equilibrium - تعادل هاردی-وینبرگNext-generation sequencing - تعیین توالی نسل بعدیcopy number variation - تنوع نسخه کپیNortheastern China - شمال شرقی چینLinkage disequilibrium - عدم تعادل پیوستگی95% confidence intervals - فاصله اطمینان 95٪Genome-wide association studies - مطالعات مرتبط با ژنومGWAS - مطالعهٔ همخوانی سراسر ژنومProtein tyrosine phosphatase - پروتئین تیروزین فسفاتازPsoriasis - پسوریازیسPolymorphisms - پلی مورفیسمjanus kinase/signal transducers and activators of transcription - ژنوس کیناز / فرستنده های سیگنال و فعال کننده های رونویسی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Psoriasis is a chronic immune-mediated disease with a complex etiology involving various genetic and immunological factors as well as environmental factors. Psoriasis is thought to be mediated by T-cells polarized to a Th17 fate. PTPN2 encodes the T-cell protein tyrosine phosphatase, which acts as a negative regulator of the JAK/STAT signaling pathways downstream of cytokines and plays a prominent role in T-cell activation, signaling and/or effector function. To evaluate the association between PTPN2 gene polymorphisms and psoriasis in the Northeastern Chinese population. A case-control study was conducted, and 398 patients with psoriasis and 397 healthy controls were genotyped for thirteen genetic polymorphisms in PTPN2. Allele analysis revealed that rs2847297, rs657555 and rs482160 polymorphisms were significantly associated with psoriasis (pâ¯=â¯0.0018, pâ¯=â¯0.0017 and pâ¯=â¯0.0086, respectively). Genotype analysis also revealed that these polymorphisms were significantly associated with psoriasis under different models (codominant, dominant and recessive models) (pâ¯<â¯0.05). In this study, three haplotypes (H1, H7 and H11) were also found to be associated with psoriasis (pâ¯=â¯0.0015, pâ¯=â¯0.0094, and pâ¯=â¯0.0124, respectively). These results indicate that PTPN2 genetic polymorphisms are associated with psoriasis in the Northeastern Chinese population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 681, 10 January 2019, Pages 73-79
Journal: Gene - Volume 681, 10 January 2019, Pages 73-79
نویسندگان
Qingbu Mei, Chang Liu, Xuelong Zhang, Qiuyan Li, Xueyuan Jia, Jie Wu, Wenjing Sun, Yuandong Qiao, Jiawei Wu, Yuzhen Li, Jingcui Yu, Songbin Fu, Lidan Xu,