Design, synthesis, and biological evaluation of novel pan agonists of FFA1, PPARγ and PPARδ

Aiming to develop potent dual PPARs/FFA1 agonists, we have hybrid the Sanofi's FFA1 agonist 1 with PPARδ agonist 2 based on their structural similarity, exemplified by the orally bioavailable FFA1/PPARγ/PPARδ pan agonist 15.306