کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11030545 | 1646278 | 2018 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of complement system in patients with biopsy-proven immunoglobulin G4-related kidney disease
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
آسیبشناسی و فناوری پزشکی
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چکیده انگلیسی
Hypocomplementemia has been frequently reported in immunoglobulin G4-related kidney disease (IgG4-RKD). However, studies on the role of complement system in IgG4-RKD are lacking. A total of 40â¯429 renal biopsies from January 2010 to January 2018 were reexamined in the present study, and 17 patients were confirmed to meet the criteria of IgG4-RKD. According to the serum C3 levels, they were divided into 2 groups: the low-C3 group (C3 <0.8â¯g/L, nâ¯=â¯7) and the normal-C3 group (C3â¯â¥0.8â¯g/L, nâ¯=â¯10). Compared with the normal-C3-level group, the patients in the low-C3-level group had lower serum C4 concentrations (Pâ¯=â¯.025), higher serum IgG4 concentrations (Pâ¯=â¯.003), higher positive rates in rheumatoid factor (Pâ¯=â¯.033), more severe storiform fibrosis (Pâ¯=â¯.007) at diagnosis, and higher blood urea nitrogen levels at the latest test (Pâ¯=â¯.04). The serum levels of C3 were in negative correlation with the serum levels of IgG4 (Pâ¯=â¯.003), the levels of rheumatoid factor (Pâ¯=â¯.002), renal deposition of C1q (Pâ¯=â¯.028), storiform fibrosis (Pâ¯<â¯.001), scores of interstitial fibrosis (Pâ¯=â¯.015), the amount of renal IgG4-positive (IgG4+) plasma cells (Pâ¯=â¯.020), the ratios of IgG4+ plasma cells/CD138+ cells (Pâ¯=â¯.018), and the blood urea nitrogen concentrations at the last test (Pâ¯=â¯.023). Our study shows that IgG4-RKD is a relatively rare entity. Complement system may participate in the development of IgG4-RKD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 81, November 2018, Pages 220-228
Journal: Human Pathology - Volume 81, November 2018, Pages 220-228
نویسندگان
Rong MD, Dafeng MD, Lili Msc, Shaoshan MD, Dandan MD, Feng MD, Mingchao Msc, Xiaodong MD, Huiping MD, Honglang MD, Caihong MD, Zheng MD, Zhihong MD,