کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
11201 724 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Scaffold fabrication by indirect three-dimensional printing
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Scaffold fabrication by indirect three-dimensional printing
چکیده انگلیسی

Three-dimensional printing (3DP) has been employed to fabricate porous scaffolds by inkjet printing liquid binder droplets onto particulate matter. Direct 3DP, where the final scaffold materials are utilized during the actual 3DP process, imposes several limitations on the final scaffold structure. This study describes an indirect 3DP protocol, where molds are printed and the final materials are cast into the mold cavity to overcome the limitations of the direct technique. To evaluate the resolution available in this technique, scaffolds with villi features (500 μm diameter, 1 mm height) were produced by solvent casting into plaster molds, followed by particulate leaching. Scanning electron microscope (SEM) showed highly open, well interconnected, uniform pore architecture (∼100–150 μm). The ability of these scaffolds to support intestinal epithelial cell (IEC6) culture was investigated in vitro. IEC6 cells attached to scaffolds uniformly in vitro and grew preferentially in the villi region. To exploit the freeform nature of this technique with large pore size, anatomically shaped zygoma scaffolds with 300–500 μm interconnected pores were produced and characterized. Indirect 3DP provides an alternative method to complement other direct solid freeform fabrication methods.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 26, Issue 20, July 2005, Pages 4281–4289
نویسندگان
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