Immune response dynamics

The consequences of regulatory TT cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We determine the analytic formula that describes the fine balance between Regulatory TT cells and TT cells at controlled and immune response equilibrium states. We demonstrate that cytokine dependent growth exhibits a quorum TT cell population threshold that determines if immune responses develop on activation. We determine the analytic formulas of TT cell proliferation thresholds that allow us to study the sensibility of the quorum growth thresholds controlling immune responses.