کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1138240 | 1489203 | 2007 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A hybrid model for tumor-induced angiogenesis in the cornea in the presence of inhibitors A hybrid model for tumor-induced angiogenesis in the cornea in the presence of inhibitors](/preview/png/1138240.png)
The present work formulates and analyzes, by means of numerical experiments, a model for tumor-induced angiogenesis in the presence of inhibitors in the cornea. Our model is a generalization of the earlier work of Tong and Yuan [S. Tong, F. Yuan, Numerical simulations of angiogenesis in the cornea, Microvascular Research 61 (2001) 14–27] to incorporate the role of inhibitors, relevant to experimental assays. The derived set of hybrid equations consists of partial differential equations for the tumor angiogenic factors and the inhibitors with a particle model for the motion of the endothelial cells. This is analyzed numerically in the two-dimensional setting. The relevant results are discussed and qualitative agreement with the experimental work is illustrated.
Journal: Mathematical and Computer Modelling - Volume 46, Issues 3–4, August 2007, Pages 513–524