کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11383 | 736 | 2006 | 9 صفحه PDF | دانلود رایگان |
A materials design of a new supramolecular hydrogel self-assembled between α-cyclodextrin and a biodegradable poly(ethylene oxide)–poly[(r)-3-hydroxybutyrate]–poly(ethylene oxide) (PEO–PHB–PEO) triblock copolymer was demonstrated. The cooperation effect of complexation of PEO segments with α-cyclodextrin and the hydrophobic interaction between PHB blocks resulted in the formation of the supramolecular hydrogel with a strong macromolecular network. The in vitro release kinetics studies of fluorescein isothiocyanate labeled dextran (dextran-FITC) model drug from the hydrogel showed that the hydrogel was suitable for relatively long-term sustained controlled release of macromolecular drugs, which many simple triblock copolymer hydrogel systems could not achieve. The hydrogel was found to be thixotropic and reversible, and can be applied as a promising injectable drug delivery system.
Journal: Biomaterials - Volume 27, Issue 22, August 2006, Pages 4132–4140