کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1138535 1489165 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Statistical models for recurrent events and death: Application to cancer events
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی کنترل و سیستم های مهندسی
پیش نمایش صفحه اول مقاله
Statistical models for recurrent events and death: Application to cancer events
چکیده انگلیسی

In many biomedical studies, subjects may experience the outcome of interest more than once over a period of observation; outcomes of this sort have been termed recurrent events. A model that is becoming increasingly popular for modeling association between recurrent survival times is the use of a frailty model. In recent years a number of papers appeared, extending the survival models to models that are suitable to handle more complex survival data as recurrent events. We present here frailty model extensions to analyze recurrent events data: cure frailty models for a mixture of susceptible and insusceptible subjects for the event of interest; nested frailty models when data are clustered at several hierarchical levels and joint frailty models for the joint analysis of recurrent events and death. We performed a semi-parametric penalized likelihood approach to estimate the different parameters. Those different models can be fitted using the R package “frailtypack”.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematical and Computer Modelling - Volume 52, Issues 7–8, October 2010, Pages 949–955
نویسندگان
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