کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1147522 | 957766 | 2012 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adaptive isotonic estimation of the minimum effective and peak doses in the presence of covariates
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موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
ریاضیات کاربردی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Adaptive isotonic estimation of the minimum effective and peak doses in the presence of covariates Adaptive isotonic estimation of the minimum effective and peak doses in the presence of covariates](/preview/png/1147522.png)
چکیده انگلیسی
We consider a problem of estimating the minimum effective and peak doses in the presence of covariates. We propose a sequential strategy for subject assignment that includes an adaptive randomization component to balance the allocation to placebo and active doses with respect to covariates. We conclude that either adjusting for covariates in the model or balancing allocation with respect to covariates is required to avoid bias in the target dose estimation. We also compute optimal allocation to estimate the minimum effective and peak doses in discrete dose space using isotonic regression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Statistical Planning and Inference - Volume 142, Issue 7, July 2012, Pages 1899-1907
Journal: Journal of Statistical Planning and Inference - Volume 142, Issue 7, July 2012, Pages 1899-1907
نویسندگان
Changfu Xiao, Anastasia Ivanova,