کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1147808 | 957798 | 2010 | 7 صفحه PDF | دانلود رایگان |

Crossover designs are popular in early phases of clinical trials and in bioavailability and bioequivalence studies. Assessment of carryover effects, in addition to the treatment effects, is a critical issue in crossover trails. The observed data from a crossover trial can be incomplete because of potential dropouts. A joint model for analyzing incomplete data from crossover trials is proposed in this article; the model includes a measurement model and an outcome dependent informative model for the dropout process. The informative-dropout model is compared with the ignorable-dropout model as specific cases of the latter are nested subcases of the proposed joint model. Markov chain sampling methods are used for Bayesian analysis of this model. The joint model is used to analyze depression score data from a clinical trial in women with late luteal phase dysphoric disorder. Interestingly, carryover effect is found to have a strong effect in the informative dropout model, but it is less significant when dropout is considered ignorable.
Journal: Journal of Statistical Planning and Inference - Volume 140, Issue 10, October 2010, Pages 2839–2845