کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1148550 | 957840 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A reanalysis of a longitudinal scleroderma clinical trial using non-ignorable missingness models
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
ریاضیات کاربردی
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![عکس صفحه اول مقاله: A reanalysis of a longitudinal scleroderma clinical trial using non-ignorable missingness models A reanalysis of a longitudinal scleroderma clinical trial using non-ignorable missingness models](/preview/png/1148550.png)
چکیده انگلیسی
When analyzing incomplete longitudinal clinical trial data, it is often inappropriate to assume that the occurrence of missingness is at random, especially in cases where visits are entirely missed. We present a framework that simultaneously models multivariate incomplete longitudinal data and a non-ignorable missingness mechanism using a Bayesian approach. A criterion measure is presented for comparing models. We demonstrate the feasibility of the methodology through reanalysis of two of the longitudinal measures from a clinical trial of penicillamine treatment for scleroderma patients. We compare the results for univariate and bivariate, ignorable and non-ignorable missingness models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Statistical Planning and Inference - Volume 137, Issue 12, 1 December 2007, Pages 3848-3858
Journal: Journal of Statistical Planning and Inference - Volume 137, Issue 12, 1 December 2007, Pages 3848-3858
نویسندگان
W. John Boscardin, Xiaohong Yan, Weng Kee Wong,