کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1150044 | 957910 | 2011 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A generalized drop-the-loser rule for multi-treatment clinical trials
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
ریاضیات کاربردی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Urn models are popular for response adaptive designs in clinical studies. Among different urn models, Ivanova's drop-the-loser rule is capable of producing superior adaptive treatment allocation schemes. Ivanova [2003. A play-the-winner-type urn model with reduced variability. Metrika 58, 1-13] obtained the asymptotic normality only for two treatments. Recently, Zhang et al. [2007. Generalized drop-the-loser urn for clinical trials with delayed responses. Statist. Sinica, in press] extended the drop-the-loser rule to tackle more general circumstances. However, their discussion is also limited to only two treatments. In this paper, the drop-the-loser rule is generalized to multi-treatment clinical trials, and delayed responses are allowed. Moreover, the rule can be used to target any desired pre-specified allocation proportion. Asymptotic properties, including strong consistency and asymptotic normality, are also established for general multi-treatment cases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Statistical Planning and Inference - Volume 137, Issue 6, 1 June 2007, Pages 2011-2023
Journal: Journal of Statistical Planning and Inference - Volume 137, Issue 6, 1 June 2007, Pages 2011-2023
نویسندگان
Ruibo Sun, Siu Hung Cheung, Li-Xin Zhang,