Empirical Bayes regression analysis with many regressors but fewer observations

In this paper, we consider the prediction problem in multiple linear regression model in which the number of predictor variables, p, is extremely large compared to the number of available observations, n  . The least-squares predictor based on a generalized inverse is not efficient. We propose six empirical Bayes estimators of the regression parameters. Three of them are shown to have uniformly lower prediction error than the least-squares predictors when the vector of regressor variables are assumed to be random with mean vector zero and the covariance matrix (1/n)XtX(1/n)XtX where Xt=(x1,…,xn)Xt=(x1,…,xn) is the p×np×n matrix of observations on the regressor vector centered from their sample means. For other estimators, we use simulation to show its superiority over the least-squares predictor.