کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1150671 | 957971 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Estimating protective vaccine efficacy from large trials with recruitment
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
ریاضیات کاربردی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Vaccine response is often random because of possible vaccine failures and variation in the immune systems of hosts. A concept of protective vaccine efficacy is defined as the mean vaccine ability to reduce individual susceptibilities to infection. The problem under study is how to measure this efficacy from data on a large vaccine trial in which participants are recruited over a period of time. First, lower and upper bounds are derived that apply for all types of protection induced by the vaccine. Then, the lower bound is shown to be a good estimator under certain conditions usually met in practice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Statistical Planning and Inference - Volume 137, Issue 3, 1 March 2007, Pages 907–914
Journal: Journal of Statistical Planning and Inference - Volume 137, Issue 3, 1 March 2007, Pages 907–914
نویسندگان
Niels Becker, Claude Lefèvre, Sergey Utev,