کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1173257 | 961664 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Glycolate and 2-phosphoglycolate content of tissues measured by ion chromatography coupled to mass spectrometry
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Glycolate and 2-phosphoglycolate content of tissues measured by ion chromatography coupled to mass spectrometry Glycolate and 2-phosphoglycolate content of tissues measured by ion chromatography coupled to mass spectrometry](/preview/png/1173257.png)
چکیده انگلیسی
Glycolate and 2-phosphoglycolate (PG) are 2-carbon monocarboxylic acids with ill-defined metabolic roles. Their concentrations have not yet been described in tissues apart from body fluids and erythrocytes. We describe the use of ion chromatography coupled with mass spectrometry (IC-MS) to quantify levels of glycolate and PG in tissue. Sample preparation and analysis can be performed within an hour. Low concentrations of glycolate (12–48 nmol/g) and PG (4–17 nmol/g) were detected in all tissues. The availability of this IC-MS assay will facilitate investigations of the origin, function, and metabolism of glycolate and PG in tissues.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytical Biochemistry - Volume 421, Issue 1, 1 February 2012, Pages 121–124
Journal: Analytical Biochemistry - Volume 421, Issue 1, 1 February 2012, Pages 121–124
نویسندگان
John Knight, Mark Hinsdale, Ross Holmes,