کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
11968 770 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Injectable and macroporous calcium phosphate cement scaffold
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Injectable and macroporous calcium phosphate cement scaffold
چکیده انگلیسی

Calcium phosphate cement (CPC) can be molded and self-hardens in vivo to form resorbable hydroxyapatite with excellent osteoconductivity. The objective of this study was to develop an injectable, macroporous and strong CPC, and to investigate the effects of porogen and absorbable fibers. Water-soluble mannitol was used as porogen and mixed with CPC at mass fractions from 0% to 50%. CPC with 0–40% mannitol was fully extruded under a syringe force of 10 n. The paste with 50% mannitol required a 100-N force which extruded only 66% of the paste. At fiber volume fraction of 0–5%, the paste was completely extruded. However, at 6% and 7.5% fibers, some fibers were left in the syringe after the paste was extruded. The injectable CPC scaffold had a flexural strength (mean±sd; n=5n=5) of (3.2±1.0) MPa, which approached the reported strengths for sintered porous hydroxyapatite implants and cancellous bone. In summary, the injectability of a ceramic scaffold, a macroporous CPC, was studies for the first time. Processing parameters were tailored to achieve high injectability, macroporosity, and strength. The injectable and strong CPC scaffold may be useful in surgical sites that are not freely accessible by open surgery or when using minimally invasive techniques.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 27, Issue 24, August 2006, Pages 4279–4287
نویسندگان
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