کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
12233 786 2005 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nucleation of biomimetic apatite in synthetic body fluids: dense and porous scaffold development
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Nucleation of biomimetic apatite in synthetic body fluids: dense and porous scaffold development
چکیده انگلیسی

The effectiveness of synthetic body fluids (SBF) as biomimetic sources to synthesize carbonated hydroxyapatite (CHA) powder similar to the biological inorganic phase, in terms of composition and microstructure, was investigated. CHA apatite powders were prepared following two widely experimented routes: (1) calcium nitrate tetrahydrate and diammonium hydrogen phosphate and (2) calcium hydroxide and ortophosphoric acid, but using SBF as synthesis medium instead of pure water. The characteristics of the as-prepared powders were compared, also with the features of apatite powders synthesized via pure water-based classical methods. The powder thermal resistance and behaviour during densification were studied together with the mechanical properties of the dense samples. The sponge impregnation process was used to prepare porous samples having morphological and mechanical characteristics suitable for bone substitution.Using this novel synthesis was it possible to prepare nanosized (≈20 nm), pure, carbonate apatite powder containing Mg, Na, K ions, with morphological and compositional features mimicking natural apatite and with improved thermal properties.After sintering at 1250 °C the carbonate-free apatite porous samples showed a surprising, high compressive strength together with a biomimetic morphology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 26, Issue 16, June 2005, Pages 2835–2845
نویسندگان
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