کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1226837 968327 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determination of urinary iodine by inductively coupled plasma mass spectrometry
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Determination of urinary iodine by inductively coupled plasma mass spectrometry
چکیده انگلیسی

BackgroundMild iodine deficiency is endemic in many countries of Europe including Belgium. Fast, accurate and specific methods for quantification of urinary iodine are needed. We describe in this report a specific ICP-MS method for the quantification of urinary iodine.MethodSamples and iodate calibrators were diluted 20 times into aqueous solution containing triton X-100, 1.5% HCl and 103Rh as an internal standard. Prior digestion or oxidation was not necessary. Results were compared with those obtained by Sandell–Kolthoff (S–K) spectrophotometric method.ResultsComparison of both methods showed good agreement. The Passing–Bablok regression between both methods was ICP-MS=0.986 (S–K)−7.51. The Bland–Altman difference plot showed a small but significant mean difference of −13.3 μg/L for ICP-MS. The between-day coefficient of variation (CV) was 13% at 89 μg/L. Limit of detection was 4 μg/L and limit of quantification was 20 μg/L. No carryover effect has been observed on series containing up to 50 samples.ConclusionThe ICP-MS method described here is fast, accurate and specific for the quantification of urinary iodine. Compared to the S–K method the urinary iodine concentrations measured by the ICP-MS method were slightly, but significantly lower. Consequently, the results of studies using S–K method should be compared with caution with those using the ICP-MS method.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Trace Elements in Medicine and Biology - Volume 22, Issue 2, 5 June 2008, Pages 162–165
نویسندگان
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