کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1250929 | 1496041 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthetic utility of sydnones to couple pharmacologically important heterocycles for antitubercular activity
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthetic utility of sydnones to couple pharmacologically important heterocycles for antitubercular activity Synthetic utility of sydnones to couple pharmacologically important heterocycles for antitubercular activity](/preview/png/1250929.png)
چکیده انگلیسی
In the present investigation we have utilized the 3-arylsydnones 1a–c to couple two biodynamic moieties in amide derivatives 7–10. The 3-arylsydnones were brominated to 4-bromo-3-arylsydnones 2a–c which further were reacted with benzotriazole/benzothiazolin-2-thione/morpholine/diphenylamine to the corresponding final compounds. The structures of the amide derivatives were confirmed by the spectral (IR, 1H NMR and Mass) and analytical data. Further, these were subjected to the antitubercular activity against Mycobacterium tuberculae (H37Rv). The morpholine 7a–c and benzotriazole 8a–c derivatives have exhibited good inhibition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arabian Journal of Chemistry - Volume 7, Issue 6, December 2014, Pages 900–905
Journal: Arabian Journal of Chemistry - Volume 7, Issue 6, December 2014, Pages 900–905
نویسندگان
Tasneem Taj, Shraddha V. Raikar, Ravindra R. Kamble,