کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1252979 | 971057 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Natural Compound Curcumin-a Channel Potentiator Rather Than a Corrector of the Defective Intracellular Processing of ÎF508 Mutant Cystic Fibrosis Transmembrane Conductance Regulator
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Cystic fibrosis(CF) is a severe genetic disease caused by the gene mutation of the cystic fibrosis transmembrane conductance regulator(CFTR) chloride channel. The most common point mutation ÎF508, which leads to impaired intracellular processing and channel gating of CFTR, appears in about 90% CF patients. The natural compound curcumin was reported to correct the processing defect of ÎF508-CFTR and proposed as a potential therapeutic drug to cure CF. In the present study, we analyzed the effect of curcumin on ÎF508-CFTR and demonstrated that curcumin can restore the impaired chloride conductance of ÎF508 mutant CFTR. The activity is rapid, reversible and cAMP-dependent. However, we couldn't reproduce the previously reported correction of the defective membrane trafficking of ÎF508-CFTR by curcumin. Therefore, curcumin may not be a superior lead compound for developing anti-CF drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Research in Chinese Universities - Volume 24, Issue 2, March 2008, Pages 200-203
Journal: Chemical Research in Chinese Universities - Volume 24, Issue 2, March 2008, Pages 200-203
نویسندگان
LIU Xin, GUAN Li, HE Cheng-yan, ZHANG Xiao-jing, XU Li-na, SHANG De-jing, MA Tong-hui, YANG Hong,