Crystal Structure, Nano-particle Morphology and Interaction with ATP of [NH3CH2CH(NH2) CH3]2 [M(VI)O2 (OC6H4O)2] (M = Mo0.6 W0.4) and Its Activity to Promote DNA Cleavage

The title complex [NH3CH2CH(NH2) CH3]2 [M(VI)O2 (OC6H4O)2] (M = Mo0.6 W0.4) was synthesized via a simple solution-phase chemical route. The determination of single crystal X-ray diffraction revealed that the title compound is crystallized in a monoclinic system with P2(1)/n space group, a = 1.0913 (10) nm, b = 1.0442 (10) nm, c = 1.8842 (19) nm, α = 90°, β = 96.530 (17)°, γ = 90°, Z = 4, and V = 2. 133 (4) nm3. The mononuclear anionic unit [M(VI) O2 (OC6H4O)2]2− displays chiral pseudo-octahedral [MO6] coordination geometry and is linked by chiral cations via hydrogen bond and π…π stacking interaction. The transmission electron microscopy images show that the title complex is comprised of nano-particles with diameters ranging from 20 to 50 nm. The NMR study shows the 1H downfield chemical shifts of [NH3CHaHbCH(NH2)CH3]+ cations in the title complex when it is mixed with adenosine-triphosphate (ATP), and the chemical shift difference between Ha and Hb is increased greatly, and most of the catecholate ligands dissociate from the central metal atoms. The DNA cleavage activity experiment reveals that DNA cleavage promoted by the title complex is lower than that by Na2MoO4 which possesses antitumor property, but higher than that by Na2WO4.