Preparation of Nicotinic Acid from Oxidation of 3-Picoline with Oxygen Under Catalysis of T(o-Cl)PPMn

The oxidation of 3-picoline to nicotinic acid took place efficiently in an ethanol solution with O2 as the oxidant under the catalysis of T(o-Cl)PPMn at 40-150 °C and 0.5-3.0 MPa oxygen pressure. The influences of temperature, oxygen pressure, reaction time, concentration of 3-picoline, concentration of sodium hydroxide, and concentration of T(o-Cl)PPMn catalyst, etc. on the production of nicotinic acid were investigated. The results show that T(o-Cl)PPMn presented excellent catalytic activity in the oxidation of 3-picoline to nicotinic acid and the yield of nicotinic acid varied greatly with the reaction temperature, oxygen pressure, T(o-Cl)PPMn concentration, etc.