کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1253246 | 971085 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of (S)-Isoserine Derivatives and 2, 2, 4-Trimethyl-3-hydroxy-4-cyclohexenecarboxylate*
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Two novel compounds(4a and 4b) were obtained by the association of 2, 2, 4-trimethyl-3-hydroxy-5-cyclohexenecarboxylate with (S)-isoserine derivatives. The space location of the hydroxyl group of compound 1 was identified via the formation of lactone 6. Fe2(SO4)3 · ÏH2O was used as the catalyst for the synthesis of lactone 6. The carboxyl group was selectively protected with diazomethane. All the products were characterized via1H NMR and mass spectra. The Docking study showed that the associations have the potential therapeutic use of DPP-IV inhibitor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Research in Chinese Universities - Volume 23, Issue 1, January 2007, Pages 18-21
Journal: Chemical Research in Chinese Universities - Volume 23, Issue 1, January 2007, Pages 18-21
نویسندگان
WANG Lei, ZHENG Qing-chuan, SONG Zhi-guang, FANG Wei-shuo, LI Ye-zhi, HUANG Hua-min,