کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1253953 971320 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metal complexes of anthranilic acid derivatives: A new class of non-competitive α-glucosidase inhibitors
ترجمه فارسی عنوان
مجموعه‌های فلزی مشتقات اسید آنترانیلیلیک: یک کلاس جدید از مهارکننده های غیررقابتی α-گلوکوزیداز
کلمات کلیدی
گلوکوزیداز الفا ؛ مشتقات اسید انترنیلیک؛ مجموعه‌های فلزی؛ مهارکننده های غیررقابتی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی

Metal complexes of anthranilic acid derivatives that constitute a novel class of non-sugar-type α-glucosidase inhibitors were synthesized and assessed in vitro for inhibitory activity. All of the Ag(I) complexes (9–16) inhibited α-glucosidase at the nanomolar scale, while 3,5-dichloroanthranilic acid silver(I) (9) was the most potent (IC50 = 3.21 nmol/L). Analysis of the kinetics of enzyme inhibition indicated that the mechanism of the newly prepared silver complexes was noncompetitive. The structure-activity relationships were also analyzed, and they are discussed in this report.

Metal complexes of anthranilic acid derivatives that constitute a novel class of non-sugar-type α-glucosidase inhibitors were synthesized and assessed in vitro for inhibitory activity. All of the Ag(I) complexes (9–16) inhibited α-glucosidase at the nanomolar scale, while 3,5-dichloroanthranilic acid silver(I) (9) was the most potent (IC50 = 3.21 nmol/L).Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 27, Issue 5, May 2016, Pages 627–630
نویسندگان
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