Stereochemical determination of tetrahydropyran-substituted xanthones from fungus Chaetomium murorum

Chaetoxanthone D (1), a new tetrahydropyran-substituted xanthone originated from polyketide pathway, together with the four known natural products chaetoxanthone C (2), alternariol methyl ether (3), alternariol (4) and 2,5-dimethyl-7-hydroxychromone (5) was isolated from a strain of Chaetomium murorum. The structures of these compounds were elucidated based on extensive spectroscopic analyses. The absolute configurations of 1 and 2 were determined by using quantum chemical electronic circular dichroism (ECD) calculations.

Chaetoxanthone D (1), a new tetrahydropyran-substituted xanthone, together with four known natural products (2–5) was isolated from a strain of Chaetomium murorum. The absolute configurations of chaetoxanthone D (1) and chaetoxanthone C (2) were determined by using quantum chemical electronic circular dichroism (ECD) calculations.Figure optionsDownload as PowerPoint slide