Y(OTf)3-catalyzed heterocyclic formation via aerobic oxygenation: An approach to dihydro quinazolinones and quinazolinones

The Y(OTf)3-catalyzed aerobic oxidative cyclization reaction for the selective synthesis of dihydroquinazolinones and quinazolinones has been developed. This method provides a practical, effective and green synthetic approach to dihydroquinazolinones and quinazolinones which both are important units in many biologically active compounds.

This method provides a green and efficient method to selectively synthesize dihydroquinazolinones and quinazolinones catalyzed by Y(OTf)3. The usage of molecular oxygen in air renders this protocol very attractive and practical.Figure optionsDownload as PowerPoint slide