کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1254043 | 971330 | 2015 | 4 صفحه PDF | دانلود رایگان |

An efficient biocatalytic process has been developed to obtain optically pure (1S,4R)-N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol which can be used as the key intermediate of ticagrelor. In this research, several N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol derivatives have been investigated in which Candida antarctica lipase B (CALB) was used to catalyze the asymmetric hydrolysis reaction. As expected, some of these substrates successfully gave (1S,4R)-N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol in >98% enantiomeric excess (ee) with conversion yields up to 45%.
An efficient biocatalytic process to obtain optically active (1S,4R)-N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol was developed by employing CALB as the catalyst and using several N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol derivatives as substrates.Figure optionsDownload as PowerPoint slide
Journal: Chinese Chemical Letters - Volume 26, Issue 11, November 2015, Pages 1431–1434