کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1254043 971330 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enantioselective synthesis of (1S,4R)-N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol by Candida antarctica lipase B
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Enantioselective synthesis of (1S,4R)-N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol by Candida antarctica lipase B
چکیده انگلیسی

An efficient biocatalytic process has been developed to obtain optically pure (1S,4R)-N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol which can be used as the key intermediate of ticagrelor. In this research, several N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol derivatives have been investigated in which Candida antarctica lipase B (CALB) was used to catalyze the asymmetric hydrolysis reaction. As expected, some of these substrates successfully gave (1S,4R)-N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol in >98% enantiomeric excess (ee) with conversion yields up to 45%.

An efficient biocatalytic process to obtain optically active (1S,4R)-N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol was developed by employing CALB as the catalyst and using several N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol derivatives as substrates.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 26, Issue 11, November 2015, Pages 1431–1434
نویسندگان
, , ,