کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1254088 | 971340 | 2015 | 5 صفحه PDF | دانلود رایگان |
The unusual tricyclo[6.4.0.04,9]dodecane framework was constructed in eight linear steps in 13% overall yield. An innovative strategy accessing the framework from bicyclo[3.3.1]nonanes was employed. The key steps involve a Robinson annulation, a base induced decarboxylation and epimerization in a single step, and an intramolecular alkylation.
The unusual tricyclo[6.4.0.04,9]dodecane framework was constructed in eight linear steps in 13% overall yield. An innovative strategy accessing the framework from bicyclo[3.3.1]nonanes was employed. The key steps involve a Robinson annulation, a base induced decarboxylation and epimerization in a single step, and an intramolecular alkylation. This approach not only provides an access to the tricyclo[6.4.0.04,9]dodecane framework, but also is a potential access to other types of cis-decalin bearing a 1,5-bridging skeleton.Figure optionsDownload as PowerPoint slide
Journal: Chinese Chemical Letters - Volume 26, Issue 2, February 2015, Pages 238–242