کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1254181 | 971354 | 2014 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design of novel bis-benzimidazole derivatives as DNA minor groove binding agents
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
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چکیده انگلیسی
A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound 9 owned the best potential, its IC50 values being 5.95 μmol/L (mononuclear tumor cell line (U937)) and 5.58 μmol/L (cervical cancer cell (HeLa)). Fluorescence and UV–vis studies showed that compound 9 could bind into the minor groove of DNA.
A new series of bis-benzimidazole derivatives were synthesized, and these compounds exhibited high anti-tumor activity by binding into the minor groove of DNA.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 25, Issue 4, April 2014, Pages 589–592
Journal: Chinese Chemical Letters - Volume 25, Issue 4, April 2014, Pages 589–592
نویسندگان
Xiu-Jun Wang, Ming-Li Yang, Lan-Ping Zhang, Tong Yao, Cheng Chen, Lian-Gang Mao, Yin Wang, Jie Wu,