1-(1-Alkylsulfonic)-3-methylimidazolium chloride as a reusable Brønsted acid catalyst for the regioselective azidolysis of epoxides under solvent-free conditions

In this study, 1-(1-alkylsulfonic)-3-methylimidazolium chloride as a new, green, and reusable Brønsted acid catalyst was prepared. In this protocol, we used for the regioselective ring-opening reactions of various epoxiodes with sodium azide to afford the corresponding β-azido alcohols in excellent yields and short reaction time under mild and neutral reaction conditions. This method offers several advantages including excellent regioselectivity, clean reactions, simple work-up procedure, a recyclable catalyst, and use of an eco-friendly catalyst.

A simple, efficient, and highly regioselective method for the synthesis of β-azido alcohols by the direct opening of various epoxiodes with sodium azide under solvent-free conditions is described. This new method appears to be competitive and alternative to the other methods previously described.Figure optionsDownload as PowerPoint slide