کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1254445 | 971375 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Studies on the binding of vinpocetine to human serum albumin by molecular spectroscopy and modeling
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The interaction between vinpocetine (VPC) and human serum albumin (HSA) in physiological buffer (pH 7.40) was investigated by fluorescence, FT-IR, UV-vis absorption and molecular modeling. VPC effectively quenched the intrinsic fluorescence of HSA via static quenching. The binding site number n and apparent binding constant Ka, corresponding thermodynamic parameters ÎG, ÎH and ÎS at different temperatures were calculated. The synchronous fluorescence and FT-IR spectra were used to investigate the structural change of HSA molecules with addition of VPC. Molecular modeling indicated that VPC could bind to the site I of HSA and hydrophobic interaction was the major acting force, which was in agreement with the binding mode study.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 23, Issue 5, May 2012, Pages 599-602
Journal: Chinese Chemical Letters - Volume 23, Issue 5, May 2012, Pages 599-602
نویسندگان
Hua Jiang, Rong Rong Chen, Hong Cui Wang, Han Lin Pu,