کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1254468 | 971376 | 2016 | 4 صفحه PDF | دانلود رایگان |
A method using N,O-bis(trimethylsilyl)acetamide/N-hydroxysuccinimide ester (BSA/NHS) as coupling agents for dipeptide synthesis is descried. The coupling reaction between N-hydroxysuccinimide (NHS) esters and amines could be performed under mild conditions with N,O-bis(trimethylsilyl)acetamide (BSA) as coupling reagent and no additional acid/base is required. All byproducts and excessive reactants are water soluble or hydrolysable and easy to eliminate through water-washing at the purification stage. Moreover, all the reactants are inexpensive and widely used in conventional drug production.
Dipeptides could be efficiently synthesized via a coupling reaction between N-hydroxysuccinimide (NHS) esters and amine under mild conditions using N,O-bis(trimethylsilyl)acetamide (BSA) as coupling reagent.Figure optionsDownload as PowerPoint slide
Journal: Chinese Chemical Letters - Volume 27, Issue 3, March 2016, Pages 357–360