کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1254512 | 971378 | 2014 | 4 صفحه PDF | دانلود رایگان |
Twelve novel dithiocarbamates containing 1,2,3-trizaoles group were prepared via one step starting from organic halides, dithiocarbamic acid prop-2-ynyl ester, and sodium azide, using a very simple catalytic system composed of copper(I) chloride and water at 70 °C. The structures of the new compounds were characterized and screened for their in vitro anti-tumor. Four of the compounds displayed varying levels of anti-tumor activity against the CDC25B.
Copper(I) chloride was found to be a highly efficient catalyst for the synthesis of dithiocarbamates containing 1,2,3-trizaoles group from organic halides, dithiocarbamic acid prop-2-ynyl ester, and sodium azide in water at 70 °C. The structures of the new compounds were characterized and screened for their in vitro anti-tumor activities.Figure optionsDownload as PowerPoint slide
Journal: Chinese Chemical Letters - Volume 25, Issue 11, November 2014, Pages 1469–1472