Synthesis of tetrahydro-β-carbolines from phthalic anhydrides and tryptamine

Tetrahydro-β-carbolines with strictosamide skeleton have been synthesized via intermolecular condensation, selective reduction, and intramolecular cyclization starting from phthalic anhydrides and tryptamine. The reactions are carried out under mild conditions with a wide range of substrates and functional groups.

Starting from phthalic anhydride and tryptamine, the synthesis of tetrahydro-β-carbolines has been described via intermolecular condensation, selective reduction and intramolecular cyclization.Figure optionsDownload as PowerPoint slide