Isolation and chemotaxonomic significance of stenine- and stemoninine-type alkaloids from the roots of Stemona tuberosa

One new stenine-type alkaloid, tuberostemonine D (1), together with five known stenine-type alkaloids (2–6) and two known stemoninine-type alkaloids (7 and 8), were isolated from the roots of Stemona tuberosa. Their structures were elucidated by extensive spectroscopic methods (IR, UV, MS, 1D and 2D NMR), and the structure of 1 was further confirmed by X-ray diffraction analysis. First simultaneous isolation of stenine- and stemoninine-type alkaloids not only added a new chemical type and increased the chemical diversity of Stemona tuberosa, but also provided chemotaxonomic clues for the close relationship between genera Stemona and Stichoneuron, and favored retaining them in the same family.

One new stenine-type alkaloid, tuberostemonine D (1), together with five known stenine-type alkaloids (2–6) and two known stemoninine-type alkaloids (7 and 8), were isolated from the roots of Stemona tuberosa, which provided chemotaxonomic clues for the close relationship between genera Stemona and Stichoneuron.Figure optionsDownload as PowerPoint slide