کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1254617 | 971382 | 2014 | 5 صفحه PDF | دانلود رایگان |
A novel fused isocoumarin skeleton has been synthesized through selective domino multicyclizations by mixing homothallic acid and 2,3-diphenylacryloyl chloride at 200 °C under catalyst and solvent free reaction conditions. Six fused rings with two stereogenic centers were assembled in a convenient one-pot operation in good yield. The resulting hexacyclic fused isocoumarin skeleton and its stereochemistry was fully characterized and unambiguously confirmed by X-ray diffraction analysis.
Isocoumarins are important synthetic targets due to their diverse biological applications. A simple, cheap and convenient one-pot method to construct novel isocoumarin framework with six fused rings and two stereogenic centers is described.Figure optionsDownload as PowerPoint slide
Journal: Chinese Chemical Letters - Volume 25, Issue 9, September 2014, Pages 1282–1286