کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1254651 | 971385 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
NMR identification of anti-influenza lead compound targeting at PAC subunit of H5N1 polymerase
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
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چکیده انگلیسی
PAC subunit from avian influenza (H5N1) viral RNA polymerase was used in this work as a target in the screening for anti-influenza agents from licorice-derived compounds. As a result, 18β-glycyrrhetinic acid was suggested to be PAC ligand by flexible docking, and was then confirmed by relaxation-edited NMR. The result of ApG primer extension assay indicated that this PAC ligand can inhibit the polymerase activity, and thus may potentially be valuable as anti-influenza lead compound. This work validated the possibility of screening polymerase inhibitors by using PAC as a target, and provided a starting point for the further discovery of new anti-influenza drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 23, Issue 1, January 2012, Pages 89–92
Journal: Chinese Chemical Letters - Volume 23, Issue 1, January 2012, Pages 89–92
نویسندگان
Lin Li, Sheng Hai Chang, Jun Feng Xiang, Qian Li, Huan Huan Liang, Ya Lin Tang, Ying Fang Liu,