کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1254724 971387 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and α-glucosidase inhibitory activity of chrysin, diosmetin, apigenin, and luteolin derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Synthesis and α-glucosidase inhibitory activity of chrysin, diosmetin, apigenin, and luteolin derivatives
چکیده انگلیسی

Several derivatives have been synthesized from chrysin, diosmetin, apigenin, and luteolin, which were isolated from diverse natural plants. The α-glucosidase inhibitory activity of these compounds was evaluated. The glucosidase inhibitory activity of all derivatives (IC50 < 24.396 μmol/L) was higher compared with that of the reference drug, acarbose (IC50 = 563.601 ± 40.492 μmol/L), and 1-deoxynojirimycin (IC50 = 226.912 ± 12.573 μmol/L). O3′,O7-Hexyl diosmetin (IC50 = 2.406 ± 0.101 μmol/L) was the most potent inhibitor identified. These compounds showed a higher inhibitory ability compared with their precursors except the luteolin derivatives. In general, the inhibitory activity of the synthetic derivatives was enhanced with long alkyl chains at positions 3′, 4′ and 7 of the flavonoid.

Twelve novel α-glucosidase inhibitors were synthesized and all derivatives showed remarkable inhibitory activity against α-glucosidase with potency better than that of acarbose and 1-deoxynojirimycin.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 25, Issue 7, July 2014, Pages 1094–1098
نویسندگان
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