کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1254843 971395 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Crystal structure and DNA binding studies of a cobalt(II) complex containing mixed-ligands of 1, 10-phenathroline and glycollic acid
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Crystal structure and DNA binding studies of a cobalt(II) complex containing mixed-ligands of 1, 10-phenathroline and glycollic acid
چکیده انگلیسی

A cobalt(II) complex containing mixed-ligands of 1, 10-phenathroline (phen) and glycollic acid (GA), [Co(GA)2(phen)] was synthesized and its structure was characterized by X-ray diffraction. The interaction of the complex with DNA was investigated by electronic absorption spectra and electrochemical methods. Electronic absorption spectrum experiments showed that after interaction with DNA, the characteristic absorption peaks of [Co(GA)2(phen)] underwent hypochromic effect as well as red-shift. Also, the binding strength of 3.8 × 104 L/mol was estimated by titration method. Electrochemical assays revealed that the redox peak currents of the complex decreased obviously accompanied by a positive shift of the formal potential after association with DNA. All these results revealed that the synthesized cobalt complex bound with DNA via an intercalation mode.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 22, Issue 8, August 2011, Pages 969–972
نویسندگان
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