کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1254907 | 971397 | 2013 | 4 صفحه PDF | دانلود رایگان |
A one pot protocol for the synthesis of dibenzodiazepinones was developed. The substituted ethyl 2-halobenzoates are cross-coupled with o-phenylenediamine utilizing a ligand-free, CuI catalyzed system, which spontaneously undergo an intramolecular N-acylation in ethylene glycol to give the corresponding products in high yields. This synthetic protocol provides a concise and efficient access to a wide variety of dibenzodiazepinone, including biologically active molecules.
A one pot protocol for the synthesis of dibenzodiazepinones was developed. The substituted ethyl 2-halobenzoates are cross-coupled with o-phenylenediamine utilizing a ligand-free, CuI catalyzed system, which spontaneously undergo an intramolecular N-acylation in ethylene glycol to give the corresponding products in high yields.Figure optionsDownload as PowerPoint slide
Journal: Chinese Chemical Letters - Volume 24, Issue 9, September 2013, Pages 825–828