کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1254912 | 971397 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A solid phase approach to PDMP analogs: A general strategy for combinatorial library
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The present work reports the first solid phase synthesis of biologically interesting d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (d-threo-PDMP) derivatives. This synthetic strategy includes facile preparation of versatile azido intermediate (5) in a relatively short sequence and the subsequent derivatization of 5, which led to a series of sulfonamide, urea and heterocycle substituted PDMP analogs (10 and 10′). With this method, a 5280-member compound library has been successfully built by IRORI Nanokan© system.
A solid phase method for the synthesis of PDMP analogs has been developed. With this synthetic strategy, a 5280-member library of PDMP derivatives has been successfully built.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 24, Issue 9, September 2013, Pages 845–848
Journal: Chinese Chemical Letters - Volume 24, Issue 9, September 2013, Pages 845–848
نویسندگان
Chun-Hong Dong, Yue-Teng Zhang, Gang Huang, Jing-Jing Dong, Hong-Xu Liu, Xian-Hai Tian, Jing Wang, Zhi-Gang Lv, Li-Na Song, Wen-Quan Yu,