A solid phase approach to PDMP analogs: A general strategy for combinatorial library

The present work reports the first solid phase synthesis of biologically interesting d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (d-threo-PDMP) derivatives. This synthetic strategy includes facile preparation of versatile azido intermediate (5) in a relatively short sequence and the subsequent derivatization of 5, which led to a series of sulfonamide, urea and heterocycle substituted PDMP analogs (10 and 10′). With this method, a 5280-member compound library has been successfully built by IRORI Nanokan© system.

A solid phase method for the synthesis of PDMP analogs has been developed. With this synthetic strategy, a 5280-member library of PDMP derivatives has been successfully built.Figure optionsDownload as PowerPoint slide