کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1254983 971401 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and anti-HBV evaluation of mono l-amino acid ester, mono non-steroid anti-inflammation drug carboxylic ester derivatives of acyclonucleoside phosphonates
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Synthesis and anti-HBV evaluation of mono l-amino acid ester, mono non-steroid anti-inflammation drug carboxylic ester derivatives of acyclonucleoside phosphonates
چکیده انگلیسی

A series of mono l-amino acid ester, mono non-steroid anti-inflammation drug (NSAID), carboxylic ester derivatives of acyclonucleoside phosphonates were prepared by using a “one pot synthesis” method and their in vitro anti-HBV activity were evaluated in HepG 2.2.15 cells. Compound 9a exhibited more potent anti-HBV activity and lower cytotoxicity than those of adefovir dipivoxil with IC50 and selective index (SI) values of 0.48 μmol/L and 763.72, respectively.

A series of mono l-amino acid ester, mono non-steroid anti-inflammation drug (NSAID) carboxylic ester derivatives of acyclonucleoside phosphonates were synthesized and their in vitro anti-HBV activity were evaluated in HepG 2.2.15 cells. Compound 9a exhibit more potent antiviral activity and lower cytotoxicity than adefovir dipivoxil with IC50 and selective index (SI) values of 0.48 μmol/L and 763.72, respectively.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 25, Issue 1, January 2014, Pages 115–118
نویسندگان
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