An efficient synthesis of functionalized tetrahydro-1H-indeno[2,1-c]pyridine derivatives by a PPh3-promoted condensation reaction between acetylene esters and 1,3-dioxo-N-aryl-2,3-dihydro-1H-indene-2-carboxamides

A reaction between 1,3-dioxo-N-aryl-2,3-dihydro-1H-indene-2-carboxamides, dialkyl acetylenedicarboxylates, and triphenylphosphine or trimethylphosphite is described as a simple and efficient method for the synthesis of 5-hydroxy-4-aryl-2,5-dihydrofuran-2,3-dicarboxylate derivatives.

A reaction between 1,3-dioxo-N-aryl-2,3-dihydro-1H-indene-2-carboxamides, dialkyl acetylenedicarboxylates, and triphenylphosphine or trimethylphosphite is described as a simple and efficient method for the synthesis of 5-hydroxy-4-aryl-2,5-dihydrofuran-2,3-dicarboxylate derivatives.Figure optionsDownload as PowerPoint slide