The preparation of a novel polydopamine-graft-poly(2-methyl-2-oxazoline) protein-resistant coating and its applications in protein separation

A novel polydopamine-graft-poly(2-methyl-2-oxazoline) (PDA-g-PMOXA) coating was prepared by immobilizing poly(2-methyl-2-oxazoline) (PMOXA) onto material surfaces through polydopamine (PDA) anchored coating for the first time. And then, the chemical composition, hydrophilicity, and protein-resistant properties of the PDA-g-PMOXA coating were studied using X-ray photoelectron spectroscopy (XPS), contact angel (CA) test, surface plasmon resonance (SPR), and quartz crystal microbalance with dissipation (QCM-D) measurement. Finally, the coating was applied to the capillary inner surface for protein separation by capillary electrophoresis (CE).

A novel polydopamine-graft-poly(2-methyl-2-oxazoline) (PDA-g-PMOXA) coating was prepared by immobilizing poly(2-methyl-2-oxazoline) (PMOXA) onto material surfaces through polydopamine (PDA) anchored coating for the first time. In addition, the protein-resistant properties and protein separation ability of the PDA-g-PMOXA coating were studied.Figure optionsDownload as PowerPoint slide