کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1255210 | 971412 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of a highly hydrophobic cyclic decapeptide by solid-phase synthesis of linear peptide and cyclization in solution
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A general method was described to synthesize a highly hydrophobic cyclic peptide, cyclo[LWLWLWLWLQ] where underlines indicate d-configuration of the amino acid, by a two-step solid-phase/solution synthesis strategy. The linear decapeptide was assembled by standard Boc chemistry on solid-phase and subsequently cyclized in solution with high efficiency and reproducibility. In subsequent purification by semi-preparative HPLC, 50% (v/v) DMF/H2O was employed as the solvent to overcome the difficulty of solubilization for the hydrophobic cyclic decapeptide and achieved a total yield of 30–35% with a purity of over 98%.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 21, Issue 4, April 2010, Pages 391–394
Journal: Chinese Chemical Letters - Volume 21, Issue 4, April 2010, Pages 391–394
نویسندگان
Jian Chen, Bei Zhang, Cao Xie, Yi Lu, Wei Wu,