کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1255232 | 971412 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparison of two thioxopeptide bond photoswitches in insect kinin
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Comparison of two thioxopeptide bond photoswitches in insect kinin Comparison of two thioxopeptide bond photoswitches in insect kinin](/preview/png/1255232.png)
چکیده انگلیسی
The photoisomerization abilities of secondary thioxopeptide bond (CS–NH) and thioxo prolyl bond (CS–N) incorporated into the C-terminal pentapeptide of insect kinin were compared. H-Phe-Phe-ψ[CS–NH]-d-Ala-Trp-Gly-NH2 and H-Phe-Tyr-ψ[CS–N]-Pro-Trp-Gly-NH2 were studied by UV–vis absorption. The isomerization energy barriers of the two segments, Ac-Phe-ψ[CS–NH]-d-Ala-NH2 and Ac-Tyr-ψ[CS–N]-Pro-NH2 picked from the two peptides, were calculated using ab initio method. The cis isomer of CS–N is more stable than that of CS–NH due to higher energy barrier, so the former is more suitable in peptide structure–activity relationship studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 21, Issue 4, April 2010, Pages 476–479
Journal: Chinese Chemical Letters - Volume 21, Issue 4, April 2010, Pages 476–479
نویسندگان
Zhi Yuan Cong, Long Fei Yang, Ling Jiang, Dan Ye, Shou Liang Dong,