Neamine-heterocycle conjugates as potential anti-HIV agents

A series of neamine-heterocycle conjugates were designed and synthesized. All new compounds displayed more potent inhibitory effect on HIV replication than neamine, among them two compounds displayed stronger anti-HIV activity than neomycin B. The results suggested that it might be a promising approach to modify neamine for the discovery of new anti-HIV agents.

Synthetic neamine-heterocycle conjugates showed potent inhibitory effect on HIV replication.Figure optionsDownload as PowerPoint slide